Heavy quark radiation in NLO+PS POWHEG generators

In this paper we deal with radiation from heavy quarks in the context of next-to-leading order calculations matched to parton shower generators. A new algorithm for radiation from massive quarks is presented that has considerable advantages over the one previously employed. We implement the algorithm in the framework of the ${\tt POWHEG-BOX}$, and compare it with the previous one in the case of the ${\tt hvq}$ generator for bottom production in hadronic collisions, and in the case of the ${\tt bb4l}$ generator for top production and decay.Comment: 14 pages, 13 figures, LaTe

Human sex development: targeted technologies to improve diagnosis

A new study of disorders of sex development presents an improved targeted next-generation sequencing approach for their diagnosis

Primary adrenal insufficiency: New genetic causes and their long-term consequences

Primary adrenal insufficiency (PAI) is a potentially life‐threatening condition that requires urgent diagnosis and treatment. Whilst the most common causes are congenital adrenal hyperplasia (CAH) in childhood and autoimmune adrenal insufficiency in adolescence and adulthood, more than 30 other physical and genetics cause of PAI have been reported. Reaching a specific diagnosis can have implications for management and for monitoring associated features, as well as for counselling families about recurrence risk in siblings and relatives. Here, we describe some recent insights into the genetics of adrenal insufficiency and associated molecular mechanisms. We discuss (a) the role of the nuclear receptors DAX‐1 (NR0B1) and steroidogenic factor‐1 (SF‐1, NR5A1) in human adrenal and reproductive dysfunction; (b) multisystem growth restriction syndromes due to gain‐of‐function in the growth repressors CDKN1C (IMAGE syndrome) and SAMD9 (MIRAGE syndrome), or loss of POLE1; (c) nonclassic forms of STAR and P450scc/CYP11A1 insufficiency that present with a delayed‐onset adrenal phenotype and represent a surprisingly prevalent cause of undiagnosed PAI; and (d) a new sphingolipidosis causing PAI due to defects in sphingosine‐1‐phosphate lyase‐1 (SGPL1). Reaching a specific diagnosis can have life‐long implications for management. In some situations, milder or nonclassic forms of these conditions can first present in adulthood and may have been labelled, “Addison's disease.

Error reporting in the healthcare

Errors are an inescapable part of medical activity. The only way organizations might be aware of errors and learn from them is through error reporting. Error reporting is a discretionary individual behavior that reflects the decision of individuals of communicating and disclosing errors to managers or supervisors, either verbally or through formal error reporting system. In this paper, we use the theoretical framework of behavioral reasoning theory to explore the reasoning processes underlying intentions to report errors in the workplace. We also investigate if the severity of error-related consequences might influence individuals’ formation of intentions. The findings of this study show that reasons, especially ‘reasons against’, are significantly associated with individuals’ intentions to report or not to report errors in the workplace over and above individuals’ attitudes, perceived control, and subjective norms (i.e. global motives). We discuss the implication of this study for theory and practice

The qT subtraction method: electroweak corrections and power suppressed contributions

Building upon the formulation of transverse-momentum resummation for heavy-quark hadroproduction, we present the first application of the qT subtraction formalism to the computation of electroweak corrections to massive lepton pairs through the Drell–Yan mechanism. We then study the power suppressed contributions to the qT subtraction formula in the parameter rcut, defined as the minimum transverse momentum of the lepton pair normalised to its invariant mass. We analytically compute the leading power correction from initial and final-state radiation to the inclusive cross section. In the case of initial-state radiation the power correction is quadratic in rcut and our analytic result is consistent with results previously obtained in the literature. Final-state radiation produces linear contributions in rcut that may challenge the efficiency of the qT subtraction procedure. We explicitly compute the linear power correction in the case of the inclusive cross section and we discuss the extension of our calculation to differential distributions

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.

DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita. This condition typically affects boys and presents as primary adrenal insufficiency in early infancy or childhood, hypogonadotropic hypogonadism at puberty and impaired spermatogenesis. Late onset forms of this condition and variant phenotypes are increasingly recognized. In contrast, disruption of SF-1 only rarely causes adrenal insufficiency, usually in combination with testicular dysgenesis. Variants in SF-1/NR5A1 more commonly cause a spectrum of reproductive phenotypes ranging from 46,XY DSD (partial testicular dysgenesis or reduced androgen production) and hypospadias to male factor infertility or primary ovarian insufficiency. Making a specific diagnosis of DAX-1 or SF-1 associated conditions is important for long-term monitoring of endocrine and reproductive function, appropriate genetic counselling for family members, and for providing appropriate informed support for young people

Transparency, Openness and Knowledge Sharing for Rebuilding and Strengthening Government Institutions

The developing of the Open Government Model is allowing an organizational revolution for public administrations, providing to citizens and entrepreneurs a better access to information and public services. It also can allow the increasing of transparency in public agencies and citizen participation, indirectly enhancing collaboration and facilitating democratic processes. Transparency and open data can be powerful tools to stimulate and support public services’ improvements, faster innovation and empower citizens’ rights. So actually many governmental organizations are reviewing and rearranging their processes, information and data to improve policies, enhance legitimacy and openness toward outside parties and citizens. An “open” public knowledge may contribute to establish a collaboration and participation culture among the main stakeholders. In this paper authors focus on a new organizational model to deliver transparent services and to improve an effective collaboration between the public administrations. The research methodology adopted is based on a theoreticaldeductive approach. The study describes general principles to come, through the case strategy, to the empirical analysis of an innovative national government portal called “Transparency Compass Portal”. It tries also to identify the distinctive aspects of some administrative services offered by several public organizations

Leptons in the proton

As is the case for all light coloured Standard Model particles, also photons and charged leptons appear as constituents in ultrarelativistic hadron beams, and admit a parton density function (PDF). It has been shown recently that the photon PDF can be given in terms of the structure functions and form factors for electron-proton scattering. The same holds for lepton PDFs. In the present work we set up a calculation of the lepton PDFs at next-to-leading order, using the same data input needed in the photon case. A precise knowledge of the lepton densities allows us to study lepton-initiated processes even at a hadron collider, with all possible combinations of same-charge, opposite-charge, same-flavour, different-flavour leptons and leptons-quarks, most of which cannot be realized in any other forseable experiment. The lepton densities in the proton are extremely small, so that their contribution to Standard Model processes is generally shadowed by processes initiated by coloured partons. We will show, however, that there are cases where these processes can be relevant, giving rise to rare Standard Model signatures and to new production channels, that can enlarge the discovery potential of New Physics at the LHC and future high energy colliders with hadrons in the initial state

Assessing natural capital value in the network of Italian marine protected areas: A comparative approach

Marine and coastal natural capital stocks provide a bundle of ecosystem services vital for human well-being. The biophysical and economic assessment of the value of natural capital stocks is much needed for achieving nature conservation goals, while ensuring the sustainable exploitation of marine resources. Marine Protected Areas (MPAs) are increasingly being established worldwide to protect and conserve natural capital stocks from anthropogenic threats. In this study, a biophysical and trophodynamic model based on the emergy accounting method was used to assess the value of natural capital for a set of Italian MPAs. In particular, the assessment focused on four main macro-habitats: 1) sciaphilic hard bottom (SHB), 2) photophilic hard bottom (PHB), 3) soft bottom (SB), and 4) Posidonia oceanica seagrass beds (PSB). The emergy method allowed the assessment of natural capital stocks in terms of direct and indirect solar energy flows invested by nature for their generation. The SHB habitat showed the highest emergy density value in most of the investigated MPAs, confirming the high convergence of input resource flows in the formation of this habitat. When considering extensive indicators, the contribution of the PSB habitat to the total value of natural capital was higher than other habitats in most MPAs. In addition, to facilitate the understanding of the results in socio-economic contexts, the biophysical values of natural capital stocks were converted into monetary units. The total value of natural capital in the investigated MPAs ranged from about 8 to 1163 M€. In conclusion, assessing the value of natural capital can support local managers and policy makers in charge for achieving nature conservation targets while ensuring the sustainable exploitation of natural resources

Assessing natural capital value in the network of Italian marine protected areas: a comparative approach

Marine and coastal natural capital stocks provide a bundle of ecosystem services vital for human well-being. The biophysical and economic assessment of the value of natural capital stocks is much needed for achieving nature conservation goals, while ensuring the sustainable exploitation of marine resources. Marine Protected Areas (MPAs) are increasingly being established worldwide to protect and conserve natural capital stocks from anthropogenic threats. In this study, a biophysical and trophodynamic model based on the emergy accounting method was used to assess the value of natural capital for a set of Italian MPAs. In particular, the assessment focused on four main macro-habitats: 1) sciaphilic hard bottom (SHB), 2) photophilic hard bottom (PHB), 3) soft bottom (SB), and 4) Posidonia oceanica seagrass beds (PSB). The emergy method allowed the assessment of natural capital stocks in terms of direct and indirect solar energy flows invested by nature for their generation. The SHB habitat showed the highest emergy density value in most of the investigated MPAs, confirming the high convergence of input resource flows in the formation of this habitat. When considering extensive indicators, the contribution of the PSB habitat to the total value of natural capital was higher than other habitats in most MPAs. In addition, to facilitate the understanding of the results in socio-economic contexts, the biophysical values of natural capital stocks were converted into monetary units. The total value of natural capital in the investigated MPAs ranged from about 8 to 1163 M€. In conclusion, assessing the value of natural capital can support local managers and policy makers in charge for achieving nature conservation targets while ensuring the sustainable exploitation of natural resources